High-Temperature Requirement A Serine Peptidase 2
A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.
Year introduced: 2018 (2000)
PubMed search builder options
Subheadings:
Tree Number(s): D08.811.277.656.300.760.431, D08.811.277.656.959.350.431, D12.776.476.075.429, D12.776.575.656, D12.776.705.625
MeSH Unique ID: D000074923
Registry Number: EC 3.4.21.108
Entry Terms:
- High Temperature Requirement A Serine Peptidase 2
- HtrA Serine Peptidase 2
- Omi Serine Protease
- Protease, Omi Serine
- Serine Protease, Omi
- Serine Protease Omi
- Omi, Serine Protease
- Protease Omi, Serine
- HtrA2 Protease
- Protease, HtrA2
- Serine Protease HTRA2
- HTRA2, Serine Protease
- Protease HTRA2, Serine
See Also: