Bestrophins
A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.
Year introduced: 2018
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Subheadings:
Tree Number(s): D12.776.157.530.400.175.063, D12.776.306.228, D12.776.543.550.450.175.063, D12.776.543.585.400.175.063
MeSH Unique ID: D000075002
Entry Terms:
- Bestrophin
- Bestrophin Family
- Bestrophin Proteins
- Bestrophin-1
- Bestrophin 1
- BEST-1 Protein
- BEST 1 Protein
- Bestrophin-2
- Bestrophin 2
- BEST-2 Protein
- BEST 2 Protein
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