DCC Receptor
A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.
Year introduced: 2018
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Subheadings:
Tree Number(s): D12.644.360.075.413, D12.776.476.075.413, D12.776.543.750.003.500, D12.776.624.776.021
MeSH Unique ID: D000075389
Entry Terms:
- Receptor, DCC
- Deleted in Colorectal Carcinoma Protein
- DCC-Netrin-1 Receptor
- DCC Netrin 1 Receptor
- Receptor, DCC-Netrin-1
- DCC Tumor Suppressor Protein
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