COP9 Signalosome Complex
A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.
Year introduced: 2018 (1995)
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Subheadings:
Tree Number(s): D05.500.139, D08.811.037.750.250, D08.811.277.656.300.887.375
MeSH Unique ID: D000075686
Registry Number: EC 3.4.19.12
Entry Terms:
- Signalosome Complex, COP9
- COP9 Signalosome (CSN)
- COP9 Signalsome
- Signalsome, COP9
- Constitutive Photomorphogenesis 9 Signalsome
- Constitutive Photomorphogenesis 9 Signalosome
- COP9 Signalosome Subunit 1
- G Protein Pathway Suppressor 1
- COP9 Signalosome Subunit 2
- COP9 Signalosome Subunit 3
- Signalosome Subunit 3
- Subunit 3, Signalosome
- FUSCA Protein 11
- Sgn3
- COP9 Signalosome Subunit 4
- COP9 Signalosome Subunit 5
- COP9 Signalosome Subunit 6
- COP9 Signalosome Subunit 7A
- COP9 Signalosome Subunit 7B
- COP9 Signalosome Subunit 8