Fanconi Anemia Complementation Group N Protein
A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.
Year introduced: 2018
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Subheadings:
Tree Number(s): D12.776.313.953, D12.776.624.776.051, D12.776.660.323
MeSH Unique ID: D000076164
Entry Terms:
- Partner and Localizer of BRCA2 Protein
- FANCN Protein
- PALB2 Protein
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