WNK Lysine-Deficient Protein Kinase 1

A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.

Year introduced: 2018

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Tree Number(s): D08.811.913.696.620.682.700.982, D12.776.476.563.982, D23.050.301.500.600.962, D23.050.705.552.600.925

MeSH Unique ID: D000076204

Registry Number: EC 2.7.11.1

Entry Terms:

• WNK Lysine Deficient Protein Kinase 1

Previous Indexing:

• Intracellular Signaling Peptides and Proteins (2005-2017)
• Minor Histocompatibility Antigens (2005-2017)
• Protein-Serine-Threonine Kinases (2005-2017)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Phosphotransferases
Phosphotransferases (Alcohol Group Acceptor)
Protein Kinases
Protein Serine-Threonine Kinases
WNK Lysine-Deficient Protein Kinase 1

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases
WNK Lysine-Deficient Protein Kinase 1

All MeSH Categories
Chemicals and Drugs Category
Biological Factors
Antigens
Antigens, Surface
Histocompatibility Antigens
Minor Histocompatibility Antigens
WNK Lysine-Deficient Protein Kinase 1

All MeSH Categories
Chemicals and Drugs Category
Biological Factors
Antigens
Isoantigens
Histocompatibility Antigens
Minor Histocompatibility Antigens
WNK Lysine-Deficient Protein Kinase 1