MRE11 Homologue Protein
A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.
Year introduced: 2018
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Subheadings:
Tree Number(s): D08.811.277.352.335.350.650, D08.811.277.352.335.375.813, D08.811.277.352.355.325.600, D08.811.277.352.365.290.250, D12.776.157.687.495, D12.776.260.539, D12.776.660.720.495
MeSH Unique ID: D000076228
Registry Number: EC 3.1.-
Entry Terms:
- Homologue Protein, MRE11
- Meiotic Recombination 11 Homolog 1 Protein
- MRE11A Protein
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