CCCTC-Binding Factor
A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.
Year introduced: 2018 (1998)
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Subheadings:
Tree Number(s): D12.776.157.687.157, D12.776.260.120, D12.776.660.235.050, D12.776.660.720.157, D12.776.664.235.050, D12.776.930.780.563
MeSH Unique ID: D000076246
Entry Terms:
- CCCTC Binding Factor
- CTCF Protein
- DNA-Binding Protein CTCF
- CTCF, DNA-Binding Protein
- DNA Binding Protein CTCF