Centromere Protein A
A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.
Year introduced: 2018 (1987)
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Subheadings:
Tree Number(s): D12.776.157.687.173, D12.776.260.123, D12.776.660.235.100, D12.776.660.720.173, D12.776.664.235.100, D23.050.422.031
MeSH Unique ID: D000076247
Entry Terms:
- CENP-A Protein
- CENP A Protein
- Centromere Autoantigens 17K
- Autoantigens 17K, Centromere
- Centromere Protein 17K
- CENPA Protein