Exenatide
A synthetic form of exendin-4, a 39-amino acid peptide isolated from the venom of the GILA MONSTER lizard (Heloderma suspectum). Exenatide increases CYCLIC AMP levels in pancreatic acinar cells and acts as a GLUCAGON-LIKE PEPTIDE-1 RECEPTOR (GLP-1) agonist and incretin mimetic, enhancing insulin secretion in response to increased glucose levels; it also suppresses inappropriate glucagon secretion and slows gastric emptying. It is used as an anti-diabetic and anti-obesity agent.
Year introduced: 2019 (1992)
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Subheadings:
Tree Number(s): D12.644.187, D20.888.300, D23.946.833.300
MeSH Unique ID: D000077270
Registry Number: 9P1872D4OL
Entry Terms:
- AC 2993
- AC 2993 LAR
- Byetta
- Bydureon
- ITCA 650
- Exendin-4
- Ex4 Peptide
- Peptide, Ex4
- Exendin 4
Pharmacologic Action: