Anaplastic Lymphoma Kinase
A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.
Year introduced: 2019 (1994)
PubMed search builder options
Subheadings:
Tree Number(s): D08.811.913.696.620.682.725.400.002, D12.776.476.568.400.002, D12.776.543.750.630.002
MeSH Unique ID: D000077548
Registry Number: EC 2.7.10.1
Entry Terms:
- NPM-ALK
- ALK Kinase
- Nucleophosmin-Anaplastic Lymphoma Kinase
- Nucleophosmin Anaplastic Lymphoma Kinase
- ALK Tyrosine Kinase Receptor
- CD246 Antigen
- Anaplastic Lymphoma Receptor Tyrosine Kinase