Mitochondrial Permeability Transition Pore
A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY.
Year introduced: 2021(1999)
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Subheadings:
Tree Number(s): D05.500.437, D12.776.543.585.475.563, D12.776.575.750.563
MeSH Unique ID: D000083162
Entry Terms:
- Mitochondrial Permeability Transition Pore (mPTP)
- mPTP Protein
- Mitochondrial Megachannel