Phase Variation

An adaptive mechanism used by microbes to avoid detection by the host or adapt to changes in environment by randomly and rapidly switch on and off of a gene by various mechanisms between on and off phases. For instance, drug tolerant MYCOBACTERIUM TUBERCULOSIS arises through rapid reversible mutations in the glpK gene through phase variation.

Year introduced: 2022

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Tree Number(s): G05.365.693

MeSH Unique ID: D000090502

Entry Terms:

• Phase Variations
• Variation, Phase
• Phasevarions
• Phasevarion
• Phase-Variable Regulons
• Phase-Variable Regulon
• Phase Variable Regulons
• Regulon, Phase-Variable

All MeSH Categories
Phenomena and Processes Category
Genetic Phenomena
Genetic Variation
Phase Variation