Proteolysis Targeting Chimera

Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME.

Year introduced: 2023

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Tree Number(s): D27.720.470.410.210.500

MeSH Unique ID: D000094243

Entry Terms:

• PROTACs
• PROTAC Proteolysis Targeting Chimera
• Proteolysis Targeting Chimeras
• Chimeras, Proteolysis Targeting
• Targeting Chimeras, Proteolysis
• Phospho-Dependent PROTACs
• Phospho Dependent PROTACs
• PhosphoPROTACs
• Cereblon-Based Small-Molecule Compounds
• Cereblon Based Small Molecule Compounds
• VHL-Based PROTACs
• VHL Based PROTACs
• MDM2 Protein-Based PROTACs
• MDM2 Protein Based PROTACs
• IAP-Based PROTACs
• IAP Based PROTACs

Previous Indexing:

• Proteolysis (2015-2022)

All MeSH Categories
Chemicals and Drugs Category
Chemical Actions and Uses
Specialty Uses of Chemicals
Laboratory Chemicals
Indicators and Reagents
Cross-Linking Reagents
Proteolysis Targeting Chimera