DNA Polymerase iota

A highly error-prone DNA polymerase. It is a member of the Y-family of DNA polymerases that are DNA DAMAGE tolerant and involved in TRANSLESION DNA SYNTHESIS. DNA polymerase iota is an orthologue of yeast Rad30. Its replication fidelity is template dependent and favors Hoogsteen base-pairing at its active site.

Year introduced: 2023 (2000)

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Tree Number(s): D08.811.913.696.445.308.300.493

MeSH Unique ID: D000094769

Registry Number: EC 2.7.7.7

Entry Terms:

• POL iota
• RAD30B
• POLiota

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Phosphotransferases
Nucleotidyltransferases
DNA Nucleotidyltransferases
DNA-Directed DNA Polymerase
DNA Polymerase iota