AIRE Protein

A transcriptional regulator primarily expressed in medullary thymic epithelial cells. It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY.

Year introduced: 2024 (1997)

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Tree Number(s): D12.776.930.123

MeSH Unique ID: D000096927

Entry Terms:

• Protein, AIRE
• APECED Protein
• Protein, APECED
• Autoimmune Regulator Protein
• Protein, Autoimmune Regulator
• Regulator Protein, Autoimmune
• Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Transcription Factors
AIRE Protein