Amanitins

Cyclic peptides extracted from carpophores of various mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species, blocking the production of mRNA and protein synthesis. These peptides are important in the study of transcription. Alpha-amanitin is the main toxin from the species Amanitia phalloides, poisonous if ingested by humans or animals.

Year introduced: 1975

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Tree Number(s): D04.345.566.050, D12.644.456.050, D12.644.641.050, D23.946.587.175

MeSH Unique ID: D000546

Entry Terms:

• Amanitin

Previous Indexing:

• Mycotoxins (1974)
• Oligopeptides (1974)
• Peptides, Cyclic (1974)

Pharmacologic Action:

• Enzyme Inhibitors
• Poisons
• Nucleic Acid Synthesis Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Polycyclic Compounds
Macrocyclic Compounds
Peptides, Cyclic
Amanitins
Alpha-Amanitin

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Peptides
Oligopeptides
Amanitins
Alpha-Amanitin

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Peptides
Peptides, Cyclic
Amanitins
Alpha-Amanitin

All MeSH Categories
Chemicals and Drugs Category
Biological Factors
Toxins, Biological
Mycotoxins
Amanitins
Alpha-Amanitin