Amiloride
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Year introduced: 1986(1972)
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Subheadings:
Tree Number(s): D03.383.679.149
MeSH Unique ID: D000584
Registry Number: 7DZO8EB0Z3
Entry Terms:
- Midamor
- Modamide
- Amiloride Hydrochloride
- Hydrochloride, Amiloride
- Amiloride Hydrochloride, Anhydrous
- Anhydrous Amiloride Hydrochloride
- Hydrochloride, Anhydrous Amiloride
- Amidal
- Amiduret Trom
- Trom, Amiduret
- Amiloberag
- Kaluril
- Midoride
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