5-Aminolevulinate Synthetase
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
Year introduced: 1998(1972)
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Subheadings:
Tree Number(s): D08.811.913.050.276
MeSH Unique ID: D000624
Registry Number: EC 2.3.1.37
Entry Terms:
- 5 Aminolevulinate Synthetase
- Synthetase, 5-Aminolevulinate
- Aminolevulinic Acid Synthetase
- Acid Synthetase, Aminolevulinic
- Synthetase, Aminolevulinic Acid
- delta-Aminolevulinate Synthase
- delta Aminolevulinate Synthase
- Synthase, delta-Aminolevulinate
- delta-Aminolevulinic Acid Synthetase
- Acid Synthetase, delta-Aminolevulinic
- delta Aminolevulinic Acid Synthetase
- Synthetase, delta-Aminolevulinic Acid
- 5-Aminolevulinate Synthase
- 5 Aminolevulinate Synthase
- Synthase, 5-Aminolevulinate
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