Antidepressive Agents, Tricyclic

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.

Year introduced: 1975

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Tree Number(s): D27.505.954.427.700.122.055

MeSH Unique ID: D000929

Entry Terms:

• Agents, Tricyclic Antidepressive
• Tricyclic Antidepressive Agent
• Agent, Tricyclic Antidepressive
• Antidepressive Agent, Tricyclic
• Tricyclic Antidepressant Drug
• Antidepressant Drug, Tricyclic
• Drug, Tricyclic Antidepressant
• Antidepressant Drugs, Tricyclic
• Drugs, Tricyclic Antidepressant
• Tricyclic Antidepressant Drugs
• Antidepressants, Tricyclic
• Tricyclic Antidepressants
• Tricyclic Antidepressive Agents
• Tricyclic Antidepressant
• Antidepressant, Tricyclic

Previous Indexing:

• Antidepressive Agents (1968-1974)

All MeSH Categories
Chemicals and Drugs Category
Chemical Actions and Uses
Pharmacologic Actions
Therapeutic Uses
Central Nervous System Agents
Psychotropic Drugs
Antidepressive Agents
Antidepressive Agents, Tricyclic