C-Peptide
The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
Year introduced: 1984(1977)
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Subheadings:
Tree Number(s): D06.472.699.587.200.500.250, D12.644.548.586.200.500.250
MeSH Unique ID: D002096
Entry Terms:
- C Peptide
- C-Peptide, Proinsulin
- C Peptide, Proinsulin
- Connecting Peptide
- Proinsulin C-Peptide
- Proinsulin C Peptide
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