Complement Pathway, Classical

Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.

Year introduced: 1991(1979)

PubMed search builder options

Subheadings:

Restrict to MeSH Major Topic.

Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): G12.274.698

MeSH Unique ID: D003171

Entry Terms:

• Classical Complement Pathway
• Complement Activation Pathway, Classical
• Classical Complement Activation Pathway

Previous Indexing:

• Complement (1966-1978)
• Complement Fixation Tests (1966-1978)

All MeSH Categories
Phenomena and Processes Category
Immune System Phenomena
Complement Activation
Complement Pathway, Classical