Complement C1

The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.

Year introduced: 2006 (1975)

PubMed search builder options

Subheadings:

Restrict to MeSH Major Topic.

Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): D12.776.124.486.274.050

MeSH Unique ID: D003172

Entry Terms:

• C1, Complement
• Complement Component 1
• Component 1, Complement
• C1 Complement
• Complement, C1
• Complement 1

Previous Indexing:

• Calcium (1966-1974)
• Complement (1968-1974)

Pharmacologic Action:

• Immunologic Factors

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Blood Proteins
Immunoproteins
Complement System Proteins
Complement C1
Complement C1q
Complement C1r
Complement C1s