Complement C5

C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.

Year introduced: 2006 (1975)

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Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): D12.776.124.486.274.450

MeSH Unique ID: D003182

Entry Terms:

• C5, Complement
• C5 Complement
• Complement, C5
• Complement 5
• Complement Component 5
• Component 5, Complement
• Complement C5, Precursor
• C5, Precursor Complement
• Precursor Complement C5
• Precursor C5
• C5, Precursor
• Pro-C5
• Pro C5
• Pro-complement 5
• Pro complement 5

Previous Indexing:

• Complement (1968-1974)
• Histamine Liberation (1966-1974)

Pharmacologic Action:

• Immunologic Factors

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Blood Proteins
Immunoproteins
Complement System Proteins
Complement C5
Complement C5a
Complement C5a, des-Arginine
Complement C5b