Debrisoquin

An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Year introduced: 1991(1973)

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Tree Number(s): D03.633.100.531.205

MeSH Unique ID: D003647

Registry Number: X31CDK040E

Entry Terms:

• Debrisoquine
• Tendor

Previous Indexing:

• Antihypertensive Agents (1966-1972)
• Isoquinolines (1969-1972)

Pharmacologic Action:

• Antihypertensive Agents
• Sympatholytics
• Adrenergic Agents

All MeSH Categories
Chemicals and Drugs Category
Heterocyclic Compounds
Heterocyclic Compounds, Fused-Ring
Heterocyclic Compounds, 2-Ring
Isoquinolines
Debrisoquin