Diphtheria Toxin

An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.

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Tree Number(s): D08.811.913.400.725.115.220, D23.946.123.305

MeSH Unique ID: D004167

Entry Terms:

• Corynebacterium Diphtheriae Toxin
• Toxin, Corynebacterium Diphtheriae

See Also:

• Diphtheria Toxoid

Pharmacologic Action:

• Poisons

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Glycosyltransferases
Pentosyltransferases
ADP Ribose Transferases
Diphtheria Toxin

All MeSH Categories
Chemicals and Drugs Category
Biological Factors
Toxins, Biological
Bacterial Toxins
Diphtheria Toxin