Ferrochelatase
A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
Year introduced: 1991(1977)
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Subheadings:
Tree Number(s): D08.811.520.500, D12.776.157.427.374.375.957, D12.776.556.579.374.375.617, D12.776.575.562
MeSH Unique ID: D005294
Registry Number: EC 4.99.1.1
Entry Terms:
- Heme Synthetase
- Synthetase, Heme
- Porphyrin-Metal Chelatase
- Chelatase, Porphyrin-Metal
- Porphyrin Metal Chelatase
- Protoheme Ferro-Lyase
- Ferro-Lyase, Protoheme
- Protoheme Ferro Lyase
- Zinc Chelatase
- Chelatase, Zinc
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