Glutamate Decarboxylase

A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.

Year introduced: 1984(1975)

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Tree Number(s): D08.811.520.224.125.250

MeSH Unique ID: D005968

Registry Number: EC 4.1.1.15

Entry Terms:

• Decarboxylase, Glutamate
• Glutamate Carboxy-Lyase
• Carboxy-Lyase, Glutamate
• Glutamate Carboxy Lyase
• Glutamic Acid Decarboxylase
• Acid Decarboxylase, Glutamic
• Decarboxylase, Glutamic Acid

Previous Indexing:

• Carboxy-Lyases (1973-1974)
• Glutamates (1973-1974)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Lyases
Carbon-Carbon Lyases
Carboxy-Lyases
Glutamate Decarboxylase