Isocitrate Dehydrogenase
An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
Year introduced: 1965(1963)
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Subheadings:
Tree Number(s): D08.811.682.047.820.475
MeSH Unique ID: D007521
Registry Number: EC 1.1.1.41
Entry Terms:
- Dehydrogenase, Isocitrate
- Isocitrate Dehydrogenase (NAD+)
- NAD Isocitrate Dehydrogenase
- Dehydrogenase, NAD Isocitrate
- Isocitrate Dehydrogenase, NAD
- Isocitrate Dehydrogenase-I
- Isocitrate Dehydrogenase I