Ivermectin

A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.

Year introduced: 1987

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Tree Number(s): D02.540.576.500.997

MeSH Unique ID: D007559

Registry Number: 70288-86-7

Entry Terms:

• Eqvalan
• Ivomec
• MK-933
• MK933
• MK 933
• Mectizan
• Stromectol

Previous Indexing:

• Anthelmintics (1966-1986)
• Antinematodal Agents (1974-1986)
• Antiprotozoal Agents (1966-1986)
• Filaricides (1973-1986)
• Insecticides (1966-1986)
• Lactones (1966-1986)

Pharmacologic Action:

• Antiparasitic Agents
• Insecticides

All MeSH Categories
Chemicals and Drugs Category
Organic Chemicals
Lactones
Polyketides
Macrolides
Ivermectin