Mixed Connective Tissue Disease

A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a speckled epidermal nuclear staining pattern on direct immunofluorescence.

Year introduced: 1979

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Tree Number(s): C17.300.540

MeSH Unique ID: D008947

Entry Terms:

• MCTD
• Connective Tissue Disease, Mixed
• Sharp Syndrome
• Syndrome, Sharp

Previous Indexing:

• Collagen Diseases (1972-1978)
• Lupus Erythematosus, Systemic (1972-1978)
• Scleroderma, Systemic (1972-1978)

All MeSH Categories
Diseases Category
Skin and Connective Tissue Diseases
Connective Tissue Diseases
Mixed Connective Tissue Disease