Myosin-Light-Chain Kinase

An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction.

Year introduced: 1987

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Tree Number(s): D08.811.913.696.620.682.700.125.500, D12.776.476.563.125.500

MeSH Unique ID: D009219

Registry Number: EC 2.7.11.18

Entry Terms:

• Kinase, Myosin-Light-Chain
• Myosin Light Chain Kinase
• Myosin LCK
• LCK, Myosin
• Myosin Kinase
• Kinase, Myosin
• Myosin Regulatory Light-Chain Kinase
• Myosin Regulatory Light Chain Kinase

Previous Indexing:

• Phosphotransferases, ATP (1966-1972)
• Protein Kinases (1973-1986)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Phosphotransferases
Phosphotransferases (Alcohol Group Acceptor)
Protein Kinases
Protein Serine-Threonine Kinases
Calcium-Calmodulin-Dependent Protein Kinases
Myosin-Light-Chain Kinase

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases
Calcium-Calmodulin-Dependent Protein Kinases
Myosin-Light-Chain Kinase