Nucleic Acid Denaturation

Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is melted by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.

Year introduced: 1970(1967)

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Tree Number(s): E05.393.640, G02.111.603, G05.627

MeSH Unique ID: D009691

Entry Terms:

• Acid Denaturation, Nucleic
• Denaturation, Nucleic Acid
• Nucleic Acid Denaturations
• DNA Denaturation
• Denaturation, DNA
• DNA Melting
• RNA Denaturation
• Denaturation, RNA

See Also:

• RNA Stability

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Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Investigative Techniques
Genetic Techniques
Nucleic Acid Denaturation

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Phenomena and Processes Category
Chemical Phenomena
Biochemical Phenomena
Nucleic Acid Denaturation

All MeSH Categories
Phenomena and Processes Category
Genetic Phenomena
Nucleic Acid Denaturation