Purpura, Thrombotic Thrombocytopenic
An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE. Mutations in the ADAMTS13 PROTEIN gene have been identified in familial cases.
Year introduced: 1986
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Tree Number(s): C15.378.100.802.687.680, C15.378.140.855.925.750.680, C15.378.243.937.925.750.680, C15.378.925.850, C23.550.414.950.687.680, C23.888.885.687.687.680
MeSH Unique ID: D011697
Entry Terms:
- Thrombocytopenic Purpura, Thrombotic
- Thrombotic Thrombocytopenic Purpura
- Purpura, Thrombotic Thrombopenic
- Thrombopenic Purpura, Thrombotic
- Thrombotic Thrombopenic Purpura
- Moschkowitz Disease
- Moschcowitz Disease
- Congenital Thrombotic Thrombocytopenic Purpura
- Schulman-Upshaw Syndrome
- Schulman Upshaw Syndrome
- Thrombotic Thrombocytopenic Purpura, Congenital
- Upshaw-Schulman Syndrome
- Upshaw Schulman Syndrome
- Upshaw Factor, Deficiency of
- Thrombotic Microangiopathy, Familial
- Familial Thrombotic Microangiopathy
- Microangiopathy, Familial Thrombotic
- Microangiopathic Hemolytic Anemia, Congenital
- Familial Thrombotic Thrombocytopenic Purpura
- Thrombotic Thrombocytopenic Purpura, Familial
- Familial Thrombotic Thrombocytopenia Purpura