Tetanus Toxin

Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.

Year introduced: 1965

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Tree Number(s): D12.776.097.872, D23.946.123.893

MeSH Unique ID: D013744

Entry Terms:

• Toxin, Tetanus
• Clostridium tetani Toxin
• Toxin, Clostridium tetani
• Tetanus Toxins
• Toxins, Tetanus
• Clostridial Neurotoxin
• Neurotoxin, Clostridial

See Also:

• Tetanus Antitoxin

Pharmacologic Action:

• Neurotoxins

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Bacterial Proteins
Tetanus Toxin

All MeSH Categories
Chemicals and Drugs Category
Biological Factors
Toxins, Biological
Bacterial Toxins
Tetanus Toxin