Trypsin Inhibitor, Kazal Pancreatic
A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premature activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS.
Year introduced: 1991(1975)
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Subheadings:
Tree Number(s): D12.644.822.750.500, D12.776.124.050.850, D12.776.815.688.500
MeSH Unique ID: D014359
Registry Number: 50936-63-5
Entry Terms:
- SPINK1
- Trypsin Inhibitor, Pancreatic Secretory
- Trypsin Inhibitor Kazal Pancreatic
- Kazal Pancreatic Trypsin Inhibitor
- Inhibitor, Tumor-Associated Trypsin
- Trypsin Inhibitor, Tumor-Associated
- Trypsin Inhibitor, Tumor Associated
- Tumor-Associated Trypsin Inhibitor
- Tumor Associated Trypsin Inhibitor
- Acidic Pancreatic Trypsin Inhibitor
- Pancreatic Secretory Trypsin Inhibitor, Kazal
- Pancreatic Trypsin Secretory Inhibitor, Kazal
- Serine Peptidase Inhibitor, Kazal-Type 1
- Serine Peptidase Inhibitor, Kazal Type 1
- Pancreatic Secretory Trypsin Inhibitor
- Serine Protease Inhibitor Kazal-Type 1
- Serine Protease Inhibitor Kazal Type 1
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