Dideoxynucleosides

Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.

Year introduced: 1989

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Tree Number(s): D13.570.230.500

MeSH Unique ID: D015224

Entry Terms:

• ddNus
• 2',3'-Dideoxynucleosides
• 2',3' Dideoxynucleosides
• Dideoxyribonucleosides

Previous Indexing:

• Deoxyribonucleosides (1971-1988)

Pharmacologic Action:

• Antimetabolites
• Antiviral Agents
• Reverse Transcriptase Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Nucleic Acids, Nucleotides, and Nucleosides
Nucleosides
Deoxyribonucleosides
Dideoxynucleosides
Didanosine
Dideoxyadenosine
Stavudine
Zalcitabine
Lamivudine
Zidovudine