Cilastatin
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
Year introduced: 1989
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Subheadings:
Tree Number(s): D02.455.426.392.368.533.200, D10.251.355.325.200
MeSH Unique ID: D015377
Registry Number: 141A6AMN38
Entry Terms:
- Cilastatin Sodium
- Sodium, Cilastatin
- Cilastatin Monosodium Salt
- Monosodium Salt, Cilastatin
- Salt, Cilastatin Monosodium
- MK 0791
- MK0791
- MK-791
- MK791
- MK 791
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