2-Amino-5-phosphonovalerate

The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Year introduced: 1990

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Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): D12.125.070.950.100, D12.125.740.025

MeSH Unique ID: D015763

Registry Number: 76726-92-6

Entry Terms:

• 2 Amino 5 phosphonovalerate
• 2-APV
• 5-Phosphononorvaline
• 5 Phosphononorvaline
• 2-Amino-5-phosphonopentanoate
• 2 Amino 5 phosphonopentanoate
• 2-Amino-5-phosphonopentanoic Acid
• 2 Amino 5 phosphonopentanoic Acid
• 2-Amino-5-phosphonovaleric Acid
• 2 Amino 5 phosphonovaleric Acid
• d-APV
• dl-APV

Previous Indexing:

• Anticonvulsants (1966-1989)
• Valine (1966-1974)
• Valine/analogs and derivatives (1975-1989)

Pharmacologic Action:

• Excitatory Amino Acid Antagonists

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Amino Acids
Amino Acids, Branched-Chain
Valine
2-Amino-5-phosphonovalerate

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Amino Acids
Phosphoamino Acids
2-Amino-5-phosphonovalerate