Proto-Oncogene Proteins c-abl
Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.
Year introduced: 1991
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Subheadings:
Tree Number(s): D08.811.913.696.620.682.725.500, D12.776.476.568.500, D12.776.624.664.700.167
MeSH Unique ID: D016315
Registry Number: EC 2.7.10.2
Entry Terms:
- c-abl, Proto-Oncogene Proteins
- Proto Oncogene Proteins c abl
- abl Proto-Oncogene Products
- abl Proto Oncogene Products
- Products, abl Proto-Oncogene
- Proto-Oncogene Products, abl
- Proto-Oncogene Proteins abl
- abl, Proto-Oncogene Proteins
- Proteins abl, Proto-Oncogene
- Proto Oncogene Proteins abl
- abl Proto-Oncogene Proteins
- abl Proto Oncogene Proteins
- Proto-Oncogene Proteins, abl
- c-abl Proteins
- c abl Proteins
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