Aphidicolin

An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.

Year introduced: 1992

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Tree Number(s): D02.455.849.291.075

MeSH Unique ID: D016590

Registry Number: 38966-21-1

Entry Terms:

• Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer
• NSC-351140
• NSC351140
• NSC 351140
• NSC-234714
• NSC234714
• NSC 234714
• ICI-69653
• ICI69653
• ICI 69653

Previous Indexing:

• Antiviral Agents (1966-1991)
• Diterpenes (1974-1991)
• DNA Polymerases/antagonists and inhibitors (1977-1991)

Pharmacologic Action:

• Antiviral Agents
• Enzyme Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Organic Chemicals
Hydrocarbons
Terpenes
Diterpenes
Aphidicolin