Negative Staining

The technique of washing tissue specimens with a concentrated solution of a heavy metal salt and letting it dry. The specimen will be covered with a very thin layer of the metal salt, being excluded in areas where an adsorbed macromolecule is present. The macromolecules allow electrons from the beam of an electron microscope to pass much more readily than the heavy metal; thus, a reversed or negative image of the molecule is created.

Year introduced: 1992

PubMed search builder options

Subheadings:

Restrict to MeSH Major Topic.

Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): E01.370.225.500.620.670.520, E01.370.225.750.600.670.520, E05.200.500.620.670.520, E05.200.750.600.670.520

MeSH Unique ID: D016624

Entry Terms:

• Staining, Negative

Previous Indexing:

• Staining (1966-1991)

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Diagnosis
Diagnostic Techniques and Procedures
Clinical Laboratory Techniques
Cytological Techniques
Histocytological Preparation Techniques
Staining and Labeling
Negative Staining

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Diagnosis
Diagnostic Techniques and Procedures
Clinical Laboratory Techniques
Histological Techniques
Histocytological Preparation Techniques
Staining and Labeling
Negative Staining

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Investigative Techniques
Clinical Laboratory Techniques
Cytological Techniques
Histocytological Preparation Techniques
Staining and Labeling
Negative Staining

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Investigative Techniques
Clinical Laboratory Techniques
Histological Techniques
Histocytological Preparation Techniques
Staining and Labeling
Negative Staining