B7-1 Antigen
A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Year introduced: 2018 (1991)
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Subheadings:
Tree Number(s): D12.776.467.150.100, D12.776.543.095.100, D23.050.301.285.100, D23.529.168.100
MeSH Unique ID: D018122
Entry Terms:
- B7 1 Antigen
- Antigen, B7-1
- Antigen, B7 1
- B7-1 Ligand
- B7 1 Ligand
- Ligand, B7-1
- B-Cell Activation Antigen
- B Cell Activation Antigen
- CD80 Antigen
- CD80 Antigens
- Antigens, CD80
- B7-1 Costimulatory Molecule
- B7 1 Costimulatory Molecule
- Costimulatory Molecule, B7-1
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