Leukocyte-Adhesion Deficiency Syndrome

Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (RECEPTORS, LEUKOCYTE-ADHESION) comprising the CD11/CD18 family of glycoproteins. The syndrome is characterized by abnormal adhesion-dependent functions, especially defective tissue emigration of neutrophils, leading to recurrent infection.

Year introduced: 1995

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Tree Number(s): C16.320.798.719, C20.673.795.719

MeSH Unique ID: D018370

Entry Terms:

• Leukocyte Adhesion Deficiency Syndrome
• Deficiency Syndrome, Leukocyte-Adhesion
• Deficiency Syndrome, Leukocyte Adhesion
• Leukocyte-Adhesion Deficiency Syndromes

Previous Indexing:

• Immunologic Deficiency Syndromes (1988-1994)
• Receptors, Leukocyte-Adhesion/deficiency (1988-1990)

All MeSH Categories
Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Genetic Diseases, Inborn
Primary Immunodeficiency Diseases
Leukocyte-Adhesion Deficiency Syndrome

All MeSH Categories
Diseases Category
Immune System Diseases
Immunologic Deficiency Syndromes
Primary Immunodeficiency Diseases
Leukocyte-Adhesion Deficiency Syndrome