ATP Binding Cassette Transporter, Subfamily B
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
Year introduced: 2019 (1999)
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Subheadings:
Tree Number(s): D09.400.430.890.020.400, D12.776.157.530.100.075, D12.776.157.530.450.074.500.500.250, D12.776.395.550.020.400, D12.776.543.550.192.400, D12.776.543.585.100.200, D12.776.543.585.450.074.500.500.250
MeSH Unique ID: D018435
Entry Terms:
- P-Glycoproteins
- P Glycoproteins
- Multidrug Resistance Proteins
- ATP-Binding Cassette, Sub-Family B Proteins
- ATP Binding Cassette, Sub Family B Proteins
- ATP Binding Cassette Transporter, Sub-Family B
- ATP Binding Cassette Transporter, Sub Family B
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