Proliferating Cell Nuclear Antigen

Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.

Year introduced: 1995

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Tree Number(s): D12.776.660.740, D23.050.290.750, D23.101.140.600

MeSH Unique ID: D018809

Entry Terms:

• Antigen, Proliferating Cell Nuclear
• PCNA

Previous Indexing:

• Nuclear Proteins (1988-1994)
• Nucleoproteins (1983-1987)

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Nuclear Proteins
Proliferating Cell Nuclear Antigen

All MeSH Categories
Chemicals and Drugs Category
Biological Factors
Antigens
Antigens, Nuclear
Proliferating Cell Nuclear Antigen

All MeSH Categories
Chemicals and Drugs Category
Biological Factors
Biomarkers
Biomarkers, Tumor
Proliferating Cell Nuclear Antigen