Sneddon Syndrome

A systemic non-inflammatory arteriopathy primarily of middle-aged females characterized by the association of LIVEDO RETICULARIS, multiple thrombotic CEREBRAL INFARCTION; CORONARY DISEASE, and HYPERTENSION. Elevation of antiphospholipid antibody titers (see also ANTIPHOSPHOLIPID SYNDROME), cardiac valvulopathy, ISCHEMIC ATTACK, TRANSIENT; SEIZURES; DEMENTIA; and chronic ischemia of the extremities may also occur. Pathologic examination of affected arteries reveals non-inflammatory adventitial fibrosis, thrombosis, and changes in the media (From Jablonski, Dictionary of Syndromes and Eponymic Diseases, 2d ed; Adams et al., Principles of Neurology, 6th ed, p861; Arch Neurol 1997 Jan;54(1):53-60). Mutations in the CECR1 gene (ADA2 protein, human) are associated with Sneddon syndrome.

Year introduced: 1996

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Tree Number(s): C10.228.140.300.750, C14.907.253.774, C17.800.862.775

MeSH Unique ID: D018860

Entry Terms:

• Syndrome, Sneddon
• Livedo Reticularis, Systemic Involvement
• Sneddon-Champion Syndrome
• Sneddon Champion Syndrome
• Syndrome, Sneddon-Champion
• Livedo Reticularis And Cerebrovascular Accidents

Previous Indexing:

• Cerebrovascular Disorders (1983-1995)
• Skin (1979-1983)
• Skin Diseases, Vascular (1993-1995)

All MeSH Categories
Diseases Category
Nervous System Diseases
Central Nervous System Diseases
Brain Diseases
Cerebrovascular Disorders
Sneddon Syndrome

All MeSH Categories
Diseases Category
Cardiovascular Diseases
Vascular Diseases
Cerebrovascular Disorders
Sneddon Syndrome

All MeSH Categories
Diseases Category
Skin and Connective Tissue Diseases
Skin Diseases
Skin Diseases, Vascular
Sneddon Syndrome