Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.

Year introduced: 1996

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Tree Number(s): E05.196.566.755

MeSH Unique ID: D019032

Entry Terms:

• Mass Spectrometry, Matrix-Assisted Laser Desorption-Ionization
• Mass Spectrometry, Matrix Assisted Laser Desorption Ionization
• Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
• Matrix Assisted Laser Desorption Ionization Mass Spectrometry
• Mass Spectroscopy, Matrix-Assisted Laser Desorption-Ionization
• Mass Spectroscopy, Matrix Assisted Laser Desorption Ionization
• Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization
• MS-MALD
• MALD-MS
• MALDI-MS
• MALDI MS
• Laser Desorption-Ionization Mass Spectrometry, Matrix-Assisted
• Laser Desorption Ionization Mass Spectrometry, Matrix Assisted
• MALDI
• Surface Enhanced Laser Desorption Ionization Mass Spectrometry
• SELDI-TOF-MS

Previous Indexing:

• Spectrum Analysis, Mass (1989-1995)

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Investigative Techniques
Chemistry Techniques, Analytical
Mass Spectrometry
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization