Troponin I
A TROPONIN complex subunit that inhibits ACTOMYOSIN ATPASE activity thereby disrupting ACTIN and MYOSIN interaction. There are three troponin I subtypes: troponin I1, I2 and I3. Troponin I3 is cardiac-specific whereas troponin I1 and I2 are skeletal subtypes. Troponin I3 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin I3 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
Year introduced: 1997
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Subheadings:
Tree Number(s): D05.500.945.925, D05.750.078.730.825.925, D12.776.210.500.910.925, D12.776.220.525.825.925
MeSH Unique ID: D019210
Entry Terms:
- Troponin-I
- Troponin I1
- Troponin I2
- Troponin I3
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