Disintegrins

A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.

Year introduced: 1997

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Tree Number(s): D12.644.138

MeSH Unique ID: D019483

Entry Terms:

• Disintegrin

Previous Indexing:

• Peptides (1992-1996)
• Venoms (1992-1994)

Pharmacologic Action:

• Platelet Aggregation Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Peptides
Disintegrins